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Results may lead to new treatments for people with severe forms of the airway disorder, researchers say, a possible inherited basis for severe asthma has been recognized by researchers, and although the findings are based on a study in mice, the discovery may someday help people.
Asthma rates have been growing in recent years. In inclined people, the illness can be triggered by a number of environmental factors, including cigarette smoke, allergens and air pollution, senior researcher Marsha Wills-Karp, director of the division of immunobiology at Cincinnati Children's Hospital Medical Center, noted in a hospital news release.
In their revise, the researchers found that an inflammation-causing protein called interleukin-17 (IL-17A) is the major cause of severe asthma-like symptoms in pests. The animals used in the study had been bred to have a genetic similarity to humans with severe susceptibility to asthma.
The finding "suggests that at some point it may be possible to treat or prevent strict forms of asthma by inhibiting pathways that drive the production of IL-17A," Wills-Karp said in the news release.
Scientists naturally caution, however, that many discoveries in animal models do not translate into therapies for humans.